What is BPC-157?
BPC-157 (Body Protection Compound-157) is a pentadecapeptide (15 amino acids) found in human gastric juice. It has demonstrated profound healing effects in preclinical studies. Unlike many other peptides, BPC-157 is stable in gastric acid, making it suitable for oral as well as injectable use. It is not yet FDA-approved, but its unique properties have made it a widely studied compound in regenerative and sports medicine.
Mechanisms of Action
BPC-157’s therapeutic potential lies in its ability to accelerate healing across various tissue types. Its mechanisms include:
- Angiogenesis: Stimulates the formation of new blood vessels, increasing circulation and nutrient delivery to damaged tissue.
- Collagen Production: Enhances fibroblast activity to improve collagen synthesis—critical for joint, tendon, and skin repair.
- Anti-Inflammatory Activity: Modulates inflammatory cytokines, reducing swelling and promoting rapid tissue recovery.
- Neuroprotection: Supports nerve regeneration and may counteract damage from traumatic brain injury or neurotoxicity.
- Gut Healing: Repairs intestinal epithelial cells and tight junctions—useful in conditions like IBD, leaky gut, and ulcers.
Learn more about its biological effects: Rupa Health Review
BPC-157 Delivery Methods
BPC-157 can be administered in multiple ways depending on the condition being treated:
1. Subcutaneous Injection (SC)
SC injections are placed under the skin, often near the area of injury for localized healing. This is the most common delivery method.
2. Intramuscular Injection (IM)
Injected into deep muscle tissue, IM provides systemic distribution and is preferred for deeper musculoskeletal injuries.
3. Oral Capsules
Thanks to its gastric stability, BPC-157 can be taken orally. Oral use is especially effective for GI issues like acid reflux, IBD, and ulcers.
4. Nasal Spray
Although still under research, nasal spray offers a promising route for neurological and brain-related uses by bypassing the blood-brain barrier. Read nasal vs injection comparison.
Recommended Dosages
While clinical trials in humans are limited, preclinical research and clinical experience provide helpful dosing guidance. Dosage is highly individual and should be discussed with a medical provider.
Common Injectable Dosages:
- 200 mcg to 500 mcg per day is typical for therapeutic support.
- Some regimens include 250 mcg twice daily or 500 mcg once daily.
Oral Dosing:
For gastrointestinal conditions, doses of 500 mcg to 1,000 mcg daily in divided capsules are common. Oral absorption may vary.
Weight-Based Dosing:
Animal studies have used 10–50 mcg/kg. The human equivalent for a 70 kg adult would be approximately 1.6–8 mg per day. Always adjust under medical supervision. Peptides.org dosage calculator
Condition-Based Dosage Examples
| Condition | Suggested Dosage | Duration |
|---|---|---|
| Muscle/Tendon Injury | 250–500 mcg daily (SC) | 2–4 weeks |
| Joint Pain/Inflammation | 300–600 mcg daily | 2–6 weeks |
| GI Disorders | 500–1,000 mcg daily (oral) | 4–8 weeks |
| Neurological Recovery | 300–500 mcg daily (IM or nasal) | 4–12 weeks |
Stacking with Other Peptides
Depending on your goals, BPC-157 can be combined with other peptides for synergistic effects:
- Tesamorelin / CJC-1295 / Ipamorelin: Enhances growth hormone release for systemic recovery.
- TB-500: Another powerful regenerative peptide, often stacked with BPC-157 for tendon, ligament, and muscle repair.
- GHK-Cu: A copper peptide with wound healing and skin rejuvenation benefits.
Treatment Duration & Cycling
Typical treatment duration ranges from 2 to 8 weeks. For chronic conditions, cycling may be repeated after a short break (e.g., 4 weeks on, 2 weeks off). There is no universal cycle rule — protocols are based on patient response and goals.
Research & Clinical Studies
- BPC-157 in muscle regeneration (PMC6271067)
- BPC-157 and neuroprotection (PMC9794587)
- Review of BPC-157 pharmacology (MDPI)
- Toxicity and safety profile (ScienceDirect)
Is BPC-157 Safe?
Animal studies show BPC-157 to be remarkably safe, even at high doses. Human side effects appear rare and mild — such as transient nausea, lightheadedness, or localized injection discomfort. However, as with any investigational compound, medical oversight is essential.
BPC-157 is not approved by the FDA for human use outside of research settings. It should be prescribed and monitored by a licensed provider.
Why Choose LeadWest Medical?
At LeadWest, we combine clinical expertise with telemedicine convenience. Our providers specialize in hormone optimization, peptide therapy, and regenerative care. Every protocol is customized, medically supervised, and built around your unique goals.
- Board-certified providers with peptide experience
- Virtual visits from the comfort of your home
- Licensed in CA, NV, and more
- Ongoing follow-up and protocol adjustments
Ready to Get Started?
Whether you’re recovering from injury, dealing with inflammation, or exploring anti-aging solutions, our team is here to guide you. Schedule your telemedicine consultation with LeadWest Medical and discover how BPC-157 might support your healing journey.
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